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Humboldt-Universität zu Berlin - Faculty of Mathematics and Natural Sciences - Department of Physics

Quantum microscopy reveals invisible bio-features

Publication in "Science Advances" with participation of the group "Nonlinear Quantum Optics" from the Department of Physics of Humboldt-Universität zu Berlin

Researchers from Humboldt-Universität zu Berlin and the Experimental and Clinical Research Center in Berlin show how quantum light can help the field of bioimaging. In their new experiment, featured on the cover of "Science Advances", the team uses entangled photons to image a bio-sample probed by "invisible" light without ever looking at that light. This avoids the usually severe problems that stem from poor performance and high price of broadband mid-IR light sources and cameras. Instead, the researchers only use a normal laser and commercial CMOS camera. This makes their mid-IR microscopy technique not only robust, fast and low noise, but also cost-effective - making it highly promising for real-world applications. They show this by taking microscopic images of a tissue sample from a mouse heart.

Figure: Quantum microscopy of a mouse heart. Entangled photons allow for the making of a high-resolution mid-IR image, using a visible light (CMOS) camera and ultralow illumination intensities. In the picture, absorption (left) and phase information (right) from a region in a mouse heart. The yellow scale bar corresponds to 0.1 mm which is about the width of a human hair.

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Publication on the Website of "Science Advances"

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