Direkt zum InhaltDirekt zur SucheDirekt zur Navigation
▼ Zielgruppen ▼

Humboldt-Universität zu Berlin - Faculty of Mathematics and Natural Sciences - Optical Systems

Humboldt-Universität zu Berlin | Faculty of Mathematics and Natural Sciences | Department of Physics | Optical Systems | Projects | High-Sensitivity and High-Specificity Breath Gas Sensor Based on Molecular Spectroscopy in the Millimeter-Wave Range

High-Sensitivity and High-Specificity Breath Gas Sensor Based on Molecular Spectroscopy in the Millimeter-Wave Range

The analysis of human breath has a large medical potential because it contains several hundreds of volatile organic compounds (VOCs) that can be attributed to certain physiological processes and pulmonary as well as non-pulmonary diseases (e.g. chronic obstructive pulmonary disease (COPD) and diabetes, respectively). Besides, it is inherently safe and non-invasive. Major VOCs in the exhaled air of a healthy human are e.g. isoprene, acetone, ethanol, and methanol. However, since the concentrations of VOCs in the breath are in the ppm to ppb range, the analysis is technically challenging and common devices are bulk, expensive, difficult to handle and limited in specificity.  

The project aims to develop a novel sensor for breath analysis with high sensitivity and high specificity. It is based on a millimeter-wave heterodyne gas spectrometer in the frequency range from 230 - 260 GHz, where many VOC molecules have spectral fingerprints due to rotational transitions. The millimeter wave transmitter and receiver with integrated on-chip antennas are fabricated in SiGe technology by the project partner Leibniz-Institut für Innovative Mikroelektronik (IHP) in Frankfurt/Oder. The mission of the Humboldt-Universität zu Berlin is the integration and evaluation of the sensor system and the analysis of the measured spectra by a multivariate data analysis. Finally, the project partner Universität Marburg will evaluate the breath analysis sensor in a medical environment.

This project is funded by the Deutsche Forschungsgemeinschaft (DFG).

high-sensitivity-and-high-specificity-breath-gas-sensor-based-on-molecular-spectroscopy-in-the-millimeter-wave-range.text.image0

Spectrum of methanol within the relevant frequency range showing several distinctive absorption features [Schmalz et al., Int. Journal of Microwave and Wireless Techn., 7, 271-278 (2015)]